Results
| PMID | 28049501 |
| Gene Name | OXTR |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 69 |
| Population details | 69 (21 endometriosis patients(17 ovarian endometriosis, 4 deep infiltrating endometriosis), 48 controls (36 cervical cancer, 12 CIN III)) |
| Age | Endometriosis: 42.3?±?3.9 yrs; Controls: 41.5?±?4.1yrs |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Reprod Biol Endocrinol. 2017 Jan 3;15(1):1. doi: 10.1186/s12958-016-0220-7. Huang, Miaomaio| Li, Xuqing| Guo, Peipei| Yu, Zhaojuan| Xu, Yuting| Wei, Zhaolian Department of Gynecology and Obstetrics, First Affiliated Hospital of Anhui Medical University, Meishan Road, Hefei, 230000, China.| Assisted Reproductive Center, First Affiliated Hospital of Anhui Medical University, Meishan Road, Hefei, 230000, China BACKGROUND: The junctional zone (JZ), also called as the endometrial-myometrial junction, is related to peristaltic-like movements in the non-pregnant uterus. Hyperperistalsis and dysperistalsis of uterus constructions might underlie many important disorders such as dysmenorrhea, infertility, endometriosis, implantation failure. The major proteins for uterine contraction of the non-pregnant uterus may be Oxytocin (OT) and oxytocin receptor (OTR). The objective of this study was to inspect the expression of OTR in isthmic and mid-fundal parts of the uterine junctional zone at different stages of the follicular cycle in patients with and without endometriosis. METHODS: Uterine biopsies containing endometrium and junctional zone were collected from the isthmic and mid-fundal parts of the anterior wall after hysterectomy. The OTR expression was evaluated by immunohistochemistry. RESULTS: In the control uterus, OTR expression in the isthmic region was significantly higher than in the fundal region in the proliferative phase (p < 0.05) but significantly lower in the secretory phase (p < 0.05). And the expression of OTR in the proliferative phase was significantly higher than that in the secretory phase in both isthmic and fundal regions (p = 0.000 and 0.049, respectively). However, in endometriosis uteri, OTR expression in the isthmic region showed no significant difference with that in the fundal region in both proliferative and secretory phases (p = 0.597 and 0.736, respectively). In both isthmic and fundal regions, OTR expression was not significantly different between the proliferative phase and secretory phase (p = 0.084 and 0.222, respectively). OTR expression in fundal regions of revised ASRM I and II endometriosis were lower than that of revised ASRM III and IV (p = 0.049). In the fundal region of JZ, the expression of OTR in ovarian endometriosis was significantly lower than that in deep infiltrating endometriosis (p = 0.046). The expression level of OTR in the funds region is positively associated with the severity of dysmenorrhea in endometriosis group (r = 0.870, p < 0.05). Comparing to normal uteri, the expression of OTR in the secretory phase was significantly higher in the endometriosis uteri (p < 0.05). In the fundus of endometriosis uteri, OTR expression was significantly higher in both the proliferative and secretory phases (p = 0.045 and 0.028, respectively). CONCLUSION: OTR expression in the JZ of women with endometriosis changes significantly, which may result in abnormal uterine contractile activity, reducing the endometriosis-related fertility and dysmenorrhea. Mesh Terms: Adult| Endometriosis/*metabolism| Endometrium/*metabolism/pathology| Female| Humans| Immunohistochemistry| Linear Models| Middle Aged| Myometrium/*metabolism/pathology| Receptors, Oxytocin/*biosynthesis| Uterine Contraction| Uterus/metabolism/p |
|